SKU: 6367119225

FGL1 Fc Chimera Protein, Human

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Description

FGL1 Fc Chimera Protein, HumanProduct Specification Species Human Synonyms FGL1, Hepassocin, HP 041, HFREP 1, LFIRE 1 Accession Q08830 Amino Acid Sequence Leu23 Ile312, with N terminal Human IgG1 Fc Expression System HEK293 Molecular Weight 60 66kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag Human Fc Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure

Product Specification


Species Human
Synonyms FGL1, Hepassocin, HP-041, HFREP-1, LFIRE-1
Accession Q08830
Amino Acid Sequence Leu23-Ile312, with N-terminal Human IgG1 Fc
Expression System HEK293
Molecular Weight 60-66kDa
Purity >95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag Human Fc Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

12 months from date of receipt, -20 to -70 °C as supplied; 6 months, -20 to -70 °C under sterile conditions after reconstitution; 1 week, 2 to 8 °C under sterile conditions after reconstitution; Please avoid repeated freeze-thaw cycles.

Reference

1、Wang J. et al. (2019) Fibrinogen-like protein 1 is a major immune inhibitory ligand of LAG-3. Cell. 176: 334–347.

2、Wu H T. et al. (2016) A novel hepatokine, HFREP1, plays a crucial role in the development of insulin resistance and type 2 diabetes. Diabetologia. 59: 1732–1742.

3、Demchev V. et al. (2013) Targeted deletion of fibrinogen like protein 1 reveals a novel role in energy substrate utilization. PLoS ONE. 8: e58084.

Background

Hepassocin, also known as Hepatocyte-derived fibrinogen-related protein 1 (HFREP-1) and Fibrinogen-Like Protein 1 (FGL1), is a liver-specific secreted protein belonging to the fibrinogen superfamily whose members share a fibrinogen domain at their C-termini. FGL1 is a 68-KD protein comprised of a disulfide bond-linked homodimer. Its carboxyl terminus contains the β and γ subunits, which are highly homologous to fibrinogen but irrelevant to coagulation-related binding sites. Under normal physiological conditions, FGL1 is secreted mainly by hepatocytes in the liver (some of which may also exist in the pancreas). It is now clear that FGL1 is the product of hepatocyte regeneration and participates in hepatocyte mitosis and liver energy utilization (including lipid metabolism and blood glucose regulation). Apart from the above functions, FGL1 can also be detected in the plasma as an acute reactant, implying that FGL1 secreted by the liver acts not only on hepatocytes (autocrine) but also on other tissues, such as muscle and brown adipose tissues (telecrine). Under stimulation by metabolic factors (hyperglycemia, hyperlipidemia, hormones, etc.), the liver secretes FGL1 and participates in the blood circulation. This function of FGL1 acts on brown adipose tissue, regulates body productivity and maintains body temperature. Moreover, FGL1 also acts on muscle tissue and affects the sensitivity of myoblasts to insulin.

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SKU: 6367119225

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Melissa A Zaring
Belleville, US
★★★★★ 5
GREAT
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Works great!! I have had dry, cracked heals for years because I don't wear shoes around the house. Even my manicurist says my heals look great!
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Reviewed in the United States on May 13, 2026
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Olivia
Charlottesville, US
★★★★★ 5
Miracle
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I wish I had before and after photos, my feet are in much better shape after using this. I still need to work on them more but I ran out pretty quickly but my feet were dry af. I used to “shave” my feet once a month this is the power of foot filing in a stick. I will never foot file again. I need to find a way to make it last longer but I think I will not need as much now that my feet are in better shape. Iykyk, get this. It’s greasy as all hell but it’s easy to apply and you can do it over a towel and then put socks on immediately before bed. I wish it was a bigger stick but it is not too pricy so it’s worth it.
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Reviewed in the United States on February 17, 2026
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Myra
Lake Worth, US
★★★★★ 4
Good buy
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Works right away. A good deal.
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Reviewed in the United States on February 22, 2026
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zuleika lara
San Leandro, US
★★★★★ 3
Pies suaves
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Te ideará bien los pies
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Reviewed in the United States on May 26, 2026
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Jwan Arroyo
Birmingham, US
★★★★★ 5
Sorpresa
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Me encantó el tamaño pero el producto sencillamente espectacular de una sola aplicada suaviza el exceso de piel muerta ready para pulir y volver a poner la pomada
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Reviewed in the United States on May 12, 2026

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