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Description
MUC18/CD146 His Tag Protein, CynomolgusProduct Specification Species Cynomolgus Synonyms MCAM, CD146, MUC18 Accession A0A5F8A4A1 Amino Acid Sequence Val24Gly559, with C terminal His Expression System HEK293 Molecular Weight 75 100kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid centrifugation.
Product Specification
| Species | Cynomolgus |
| Synonyms | MCAM, CD146, MUC18 |
| Accession | A0A5F8A4A1 |
| Amino Acid Sequence | Val24–Gly559, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 75-100kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Fritzsche F R. et al. (2008) CD146 protein in prostate cancer: revisited with two different antibodies. Pathology. 40(5): 457-464. 2、Bidlingmaier S. et al. (2009) Identification of MCAM/CD146 as the target antigen of a human monoclonal antibody that recognizes both epithelioid and sarcomatoid types of mesothelioma. Cancer Res. 69(4): 1570-1577. 3、Boneberg E M. et al. (2009) Soluble CD146 is generated by ectodomain shedding of membrane CD146 in a calcium-induced, matrix metalloprotease-dependent process. Microvasc Res. 78(3): 325-331. |
Background
CD146, also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. The stromal vascular fraction (SVF) isolated from adipose tissue has been shown to be beneficial for treating peripheral nerve injuries. Micronized cellular adipose matrix (MCAM) is a SVF-rich micronized fat tissue obtained by a series of simple mechanical processes. The aim of this study is to assess the therapeutic effect of MCAM for peripheral nerve injury. An ANC filled with MCAM was implanted into a sciatic nerve defect in immunodeficient mice. Comparisons of this treatment with an autograft, an ANC filled with SVF cells, and an ANC alone were made based on electrophysiologic characteristics, sciatic function index, histological analyses of regenerated nerve fiber and myelination using electron microscopy, and the preventive effect on innervated muscle atrophy. These effects were significantly improved than in the control group (ANC only) and comparable to those in the SVF group, whereas the improvement did not reach the same level of autograft group.Injection of MCAM into an ANC accelerated nerve regeneration compared with use of an ANC alone and this effect, which indicate that MCAM is a promising transplant material for treatment of peripheral nerve injury and an alternative to use of SVF cells.
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4.3 ★★★★★
Based on 15 reviews
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Product Reviews
★★★★★ 4
works great except on windows
Size: 32 Fl Oz (Pack of 1), Style: Fresh
I bought this to clean everything (dash, door trim and jambs, custom floor mats, infotainment system, center console, windows) but my leather seats and it cleans well and dries quickly without leaving behind that sticky and unnatural shine which is what I prefer. if you like everything having that “wet” look, this isn’t the product for you. my one complaint is that it absolutely does not leave a steak free finish on windows which is fine as I should probably own stock in Sprayway at this point. I was just hoping to carry one less cleaning product but this eliminated 2 so I count that as a win.
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Reviewed in the United States on May 29, 2026
★★★★★ 5
Chemical Guys Total Interior Cleaner & Protectant 16oz
Size: 16 Fl Oz (Pack of 1), Style: Fresh
A True All-in-One Interior Cleaner That Delivers
The Chemical Guys Total Interior Cleaner & Protectant has quickly become one of my favorite detailing products. If you’re like me and want one product that can handle multiple surfaces inside your car, this is about as close to perfect as it gets. It’s versatile, effective, and safe to use on just about everything, which makes it a huge time-saver compared to juggling several specialized cleaners.
What stands out most is the versatility. I’ve used this on my dashboard, touchscreen, center console, door panels, leather seats, steering wheel, and even glass with excellent results. It wipes away dust, light dirt, fingerprints, and smudges with ease, and it doesn’t leave behind streaks or any sticky residue. The finish is clean and natural—there’s no over-the-top greasy shine, just a subtle, refreshed look that makes the whole interior feel new again.
Another highlight is the built-in UV protection. Living in a sunny area, I’ve seen dashboards and plastics fade or crack over time. Knowing this cleaner has UV blockers gives me peace of mind that I’m not just cleaning but also protecting the surfaces from long-term damage. That’s a major plus that many other interior cleaners don’t provide in one step.
The scent is another nice touch. It has a fresh, light smell that makes the car feel clean without being overpowering or artificial. Some cleaners leave behind strong chemical odors, but this one is subtle enough that it doesn’t clash with air fresheners or linger too heavily after use.
Application is simple. Spray it directly on the surface or onto a microfiber cloth, wipe, and you’re done. It doesn’t streak screens or glass, which honestly surprised me the first time I used it—I expected at least some hazing, but it left my infotainment screen spotless. It’s also gentle enough that I don’t worry about damaging sensitive areas like electronics or leather.
In terms of performance, I can’t really find any negatives. For deep stains or heavily neglected interiors, you might need more specialized products, but as a general maintenance cleaner, this is exactly what I want. It keeps the whole car interior looking clean and well-maintained without having to carry around a shelf full of different sprays.
Overall, the Chemical Guys Total Interior Cleaner & Protectant is a must-have for anyone serious about keeping their car in great condition. It’s versatile, easy to use, smells pleasant, and adds UV protection on top of cleaning power. I’d recommend it to anyone—from casual car owners who just want a quick wipe-down solution to enthusiasts who detail regularly.
For me, this is a solid 5-star product—an all-in-one solution that lives up to its promise and makes interior detailing faster and easier.
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Reviewed in the United States on September 9, 2025
★★★★★ 5
Worth it.
Size: 16 Fl Oz (Pack of 1), Style: Fresh
Love this products. Regret not getting this sooner or even the kit. But super good, and actually smells pretty good no harsh chemical smell. Removed any stained I had with such easy. Which made application easy, just spray on microfiber towel and wipe away. A little expensive but again my fault for not going with the kit.
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Reviewed in the United States on May 16, 2026
★★★★★ 5
Consumer
Size: 16 Fl Oz (Pack of 1), Style: Fresh
It’s just a great cleaner no residue you don’t need a lot of it. No weird or funky stink to it. It just cleans.
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Reviewed in the United States on May 30, 2026
★★★★★ 3
Not effective as a cleaner
Size: 16 Fl Oz (Pack of 1), Style: Fresh
If you’re looking for a cleaner, this ain’t it. It’s about as effective as water on plastic.
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Reviewed in the United States on May 25, 2026