SKU: 35421432288

FITC-Labeled EGFR Fc Chimera Protein, Human

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Description

FITC-Labeled EGFR Fc Chimera Protein, HumanProduct Specification Species Human Synonyms EGFR, ERBB, ERRP, HER1, mENA, ERBB1 Accession P00533 Amino Acid Sequence Leu25 Ser645, with C terminal Human IgG1 Fc

Product Specification


Species Human
Synonyms EGFR, ERBB, ERRP, HER1, mENA, ERBB1
Accession P00533
Amino Acid Sequence Leu25-Ser645, with C-terminal Human IgG1 Fc LEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
Expression System HEK293
Molecular Weight 110-125kDa
Purity >95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation FITC
Tag Human Fc Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4, 5% trehalose
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1、Schlessinger J. (2000) Cell signaling by receptor tyrosine kinases. Cell. 103(2): 211-225.

2、Giaccone G. (2005) HER1/EGFR-targeted agents: predicting the future for patients with unpredictable outcomes to therapy. Ann. Oncol. 16(4): 538-548.

3、Yarden Y. et al. (2001) Untangling the ErbB signalling network. Nat Rev Mol Cell Biol. 2(2): 127-137.

Background

The Epidermal Growth Factor Receptor (EGFR)is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). EGFR is activated after homodimerization or heterodimerization. Heterodimerization is an important mechanism that allows the activation of all EGFR in response to ligand stimulation. The activated EGFR binds to many signaling proteins and stimulates the activation of many signaling pathways. The specificity and potency of intracellular signaling pathways are determined by positive and negative regulators, the specific composition of activating ligand(s), receptor dimer components, and the diverse range of proteins that associate with the tyrosine phosphorylated C-terminal domain of the EGFR.EGFR is overexpressed or mutated in many cancers, especially in breast cancer, ovarian cancer, and non-small cell lung cancer. The overexpression and overactivation of EGFR is correlated with poor prognosis, drug resistance, cancer metastasis, and lower survival rate.
Shipping Notes
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Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
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  • To process your return/exchange, please contact us at [email protected]
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SKU: 35421432288

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Joel
Omaha, US
★★★★★ 5
Producto muy bueno
Size: 10, Color: Light Grey
Muy buena calidad lo recomiendo
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Reviewed in the United States on May 22, 2026
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Vasantha Prabu
Phoenix, US
★★★★★ 4
Proper fit and looks amazing
Size: 14, Color: White
Good but had to return
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Reviewed in the United States on May 13, 2026
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Ver mas San agustin
Grantham, US
★★★★★ 5
Bonito
Size: 3, Color: White
Bonito. Buena calidad
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Reviewed in the United States on March 8, 2026
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nnoyes
Whiting, US
★★★★★ 5
Great quality!
Size: 8, Color: Beige
I ordered this suit for my seven-year-old son to wear to his sister‘s wedding. The color is as pictured. It’s better quality than I thought it would be and the fit is perfect! I highly recommend purchasing this one. So worth the money!
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Reviewed in the United States on December 22, 2025
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Debbie Harrell
Louisville, US
★★★★★ 3
Fine but not great
It fit well and looked ok. However the material was thinner and flimsier than I expected. It was quite wrinkled and I couldn’t iron it well without risking melting it due to the polyester content. After ironing for about an hour on low heat it was passable but it was a lot of work to only get a passable result.
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Reviewed in the United States on November 13, 2025

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