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Description
ATP7A Recombinant Rabbit mAb (S-2289-106)Product Specification Host Rabbit Antigen ATP7A Synonyms Copper transporting ATPase 1; Copper pump 1; Menkes disease associated protein; MC1; MNK Immunogen Synthetic Peptide Location Cell membrane Accession Q04656 Clone Number S 2289 106 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample A549, HeLa, SH SY5Y, mouse lung, C6 Predicted Reactivity Hm Purification Protein A Concentration 0. 5 mg ml
Product Specification
| Host | Rabbit |
| Antigen | ATP7A |
| Synonyms | Copper-transporting ATPase 1; Copper pump 1; Menkes disease-associated protein; MC1; MNK |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | Q04656 |
| Clone Number | S-2289-106 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | A549, HeLa, SH-SY5Y, mouse lung, C6 |
| Predicted Reactivity | Hm |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:200 | Hu, Ms, Rt |
Background
ATP7A (Menkes ATPase) is a copper-transporting P-type ATPase that uses ATP hydrolysis to actively pump Cu(I) across membranes, thereby maintaining cellular copper homeostasis: under normal or low copper conditions it resides in the trans-Golgi network (TGN) and delivers copper to cuproenzymes (e.g., peptidyl-α-monooxygenase, tyrosinase, lysyl oxidase), while under high copper it traffics to the plasma membrane to efflux excess copper; the 1,500-amino-acid protein contains eight transmembrane segments forming a copper channel, an ATP-binding domain, and six N-terminal cytosolic Cu(I)-binding GMTCXXC motifs, and mutations in ATP7A cause the X-linked disorder Menkes disease, characterized by systemic copper deficiency, neurodegeneration, and early death.
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